DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions

نویسندگان

چکیده

Abstract DNA molecules are subject to various lesions that can be detrimental the cells. damage response (DDR) pathways encompass a variety of mechanisms cells employ in damage. While DDR promotes genomic stability normal cells, it also protects cancer from lesions, particularly against exogenous DNA‐damaging agents. Therefore, exploited account for resistance chemotherapy and radiotherapy have potential targeted treatment. Apart poly (ADP‐ribose) polymerase (PARP) inhibitors used BRCA‐mutant cancers, other being developed tested clinical trials. Based on synthetic lethality theory, combination therapies utilizing been explored currently undergoing trials, with promising results Combination typically inhibitor sensitize traditional chemotherapeutic agents, radiotherapy, immunotherapy, even PARP inhibitors. Herein, we focus recent advances inhibitor‐based than inhibitors, explore advantages disadvantages strategies, discuss current challenges future perspectives.

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ژورنال

عنوان ژورنال: Aging and cancer

سال: 2022

ISSN: ['2643-8909']

DOI: https://doi.org/10.1002/aac2.12047