DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions
نویسندگان
چکیده
Abstract DNA molecules are subject to various lesions that can be detrimental the cells. damage response (DDR) pathways encompass a variety of mechanisms cells employ in damage. While DDR promotes genomic stability normal cells, it also protects cancer from lesions, particularly against exogenous DNA‐damaging agents. Therefore, exploited account for resistance chemotherapy and radiotherapy have potential targeted treatment. Apart poly (ADP‐ribose) polymerase (PARP) inhibitors used BRCA‐mutant cancers, other being developed tested clinical trials. Based on synthetic lethality theory, combination therapies utilizing been explored currently undergoing trials, with promising results Combination typically inhibitor sensitize traditional chemotherapeutic agents, radiotherapy, immunotherapy, even PARP inhibitors. Herein, we focus recent advances inhibitor‐based than inhibitors, explore advantages disadvantages strategies, discuss current challenges future perspectives.
منابع مشابه
Anthrax prophylaxis: recent advances and future directions
Anthrax is a serious, potentially fatal disease that can present in four distinct clinical patterns depending on the route of infection (cutaneous, gastrointestinal, pneumonic, or injectional); effective strategies for prophylaxis and therapy are therefore required. This review addresses the complex mechanisms of pathogenesis employed by the bacterium and describes how, as understanding of thes...
متن کاملMolecular epidemiology: recent advances and future directions.
In 1982 we proposed the concept and a framework for implementing molecular cancer epidemiology. Here, we review progress during the past 17 years in validating and applying this approach to cancer prevention. There have been major advances, notably in the understanding of environment-susceptibility interactions in human cancer. However, a review of major findings to date reveals several urgent ...
متن کاملRecent advances and future directions in trauma care.
Now, we come to offer you the right catalogues of book to open. recent advances and future directions in trauma care an issue of surgical clinics is one of the literary work in this world in suitable to be reading material. That's not only this book gives reference, but also it will show you the amazing benefits of reading a book. Developing your countless minds is needed; moreover you are kind...
متن کاملGastric Cancer Genomics: Advances and Future Directions
Advancement in the field of cancer genomics is revolutionizing the molecular characterization of a wide variety of different cancers. Recent application of large-scale, next-generation sequencing technology to gastric cancer, which remains a major source of morbidity and mortality throughout the world, has helped better define the complex genomic landscape of this cancer. These studies also hav...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging and cancer
سال: 2022
ISSN: ['2643-8909']
DOI: https://doi.org/10.1002/aac2.12047